Loneliness is among the many symptoms of depression, but those who suffer are hardly alone. Depression affects 16 million Americans annually and is a leading cause of disability leave from the workplace. Even mild-to-moderate depression and anxiety can put strain on a person’s work, relationships, and ability to enjoy life. Feelings of isolation, low self-esteem, and lack of motivation make it easy to fall into unhealthy habits. In some cases this can mean turning to food, alcohol, or other substances instead of addressing the real problem. Depression has both physical and emotional consequences on a person’s health, and treating it can make a dramatic difference.